Another limitation of our study is that the included RCTs used different semaglutide doses (0.5, 1.0, and 2.4 mg) and administration routes (oral and subcutaneous), which may introduce heterogeneity and complicate the interpretation of pooled outcomes
Root-mean square deviation and fluctuation analysis Root-mean-square deviation (RMSD) is the most frequently used measure for structure comparison in structural biology, including monitoring the structural changes or characterizing the quality of the structure in protein folding and dynamics 76,77
Intramuscular injections of hydroxocobalamin every three months after initial treatment is shown to maintain serum cobalamin levels within normal range for several years
It can also effectively regulate dysbiosis of the gut microbiota, enhance the production of short-chain fatty acids, contribute to maintaining intestinal homeostasis, inhibit inflammation, and restore intestinal barrier integrity (Wang et al., 2023)