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Table of Contents How Retatrutide Affects Heart Rate Retatrutide increases resting heart rate primarily through GLP-1 receptor-mediated chronotropic effects at the sinoatrial node, potentially amplified by its glucagon receptor agonism, which independently raises heart rate and cardiac contractility

Similarly, individuals with a higher percentage of body fat may require a longer time for GLP-1 medication to fully suppress appetite due to differences in drug distribution and metabolism