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I have read that a mega dose of b12 apparently changes the 'friendly' skin bacteria to bad bacteria which causes the acne eruptions

Research-grade 5-Amino-1MQ refers to laboratory-use material tested for purity, analytical consistency, and controlled research applications

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosyl methionine (SAM)