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Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, and certain kidney or pancreatic conditions

The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

Some people may need extra monitoring for medications that require precise dosing

Wegovy follows a structured dose-escalation schedule over 1620 weeks, whilst topiramate is usually increased slowly over several weeks