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The higher efficacy of phenformin compared with metformin seems to be due to different modes of entry into cells

The insulin syringe is for drawing individual doses after reconstitution

Prx1 Cys83 binds to cullin-3, a ubiquitin ligase modulating Nrf2 ubiquitination [150] , and thereby inhibits degradation of Nrf2 allowing transcription of anti-ferroptotic enzymes [149]