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In the D-Gal + FOXO4-DRI group, mice also received D-galactose injections and, after 4 weeks, were given intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days for 4 weeks, followed by tissue collection

Moreover, OW semaglutide 2.4 mg has been recently proven safe and effective in reducing BW, HbA1c and lipids in patients with MASH-related compensated cirrhosis, yet failed to improve fibrosis or induce MASH resolution vs