With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (64, 66, 67) ( Figures 1AC )
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However, higher doses may result in unwanted effects such as abnormal tissue growth and organ stress in test models
Orlistat (Xenical): This drug doesnt appear to cause constipation, but it does cause other GI side effects like oily stools and urgency with bowel movements