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Riboflavin also plays a role in thyroxine metabolism, and its deficiency may contribute to mental illness, because riboflavin activates vitamin B6, leading to lower thyroxine levels, reduced hypothalamic serotonin synthesis, and decreased levels of S-adenosylmethionine (SAMe), because of disrupting the folate-methylation pathways involved in SAMe synthesis, all of which are associated with antidepressant effects, consequently, low levels of these compounds may cause depression ( Figure 4 ) (48, 49)

Glutathione is generated in the small intestines, kidney, and liver by the gamma-glutamyl cycle

Zamboni, M., Llorens-Bobadilla, E., Magnusson, J

Early diagnosis of oral candidiasis, often based on clinical examination of oral lesions, medical history, and assessment of risk factors, is particularly important for elderly and immunocompromised patients 4