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3) Tissue damage and unintended injury Injections placed too superficially, too deeply, or in the wrong anatomical plane can cause complications such as: significant inflammation and swelling skin irritation or blistering nodules and firmness under the skin uneven contouring damage to nerves or blood vessels in rare cases The submental region is anatomically complex

This returns the body to its previous state of defending a higher weight or set point, making weight regain highly likely without strong behavioral changes

Cancer cachexia: more than skeletal muscle wasting

Binding to HSA causes an increase in hydrodynamic volume, which slows renal clearance 13,14