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This accumulation of reactive oxygen species (ROS) disrupts meiotic spindle assembly, impairs spindle assembly checkpoint signaling, compromises chromatin cohesion, and ultimately deteriorates oocyte quality and developmental potential in women of advanced reproductive age ( At the molecular level, several antioxidant interventions exert their protective effects through the activation of key cellular defense pathways as shown in Figure 3

The most common deficiencies involved vitamin B12, vitamin D, and folate

GSH and AsA are the principal antioxidants in the lens, however, the levels of these compounds can become depleted with age, resulting in oxidative stress and, subsequently, mixed disulphide formation, protein aggregation, light scattering, and ultimately cataract formation