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Additionally, comparing the expression of miRNA in seminal EVs between patients with normal and impaired spermatogenic function revealed high sensitivity and specificity for diagnosing oligozoospermia, and also helped predict whether individuals with severe spermatogenic disorders had residual spermatogenesis ( However, although EVs show great potential in the diagnosis and treatment of asthenozoospermia, they are still in the research stage

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Dose escalation protocols used in trials were designed to minimise gastrointestinal tolerability issues