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To generalize this approach to polyprotic acids with coupled sites of (de)protonation, typical in complex drug-like molecules, we reformulate this expression in terms of the "neutral fraction" , the fraction of total material which is in a neutral microstate (i.e

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The essential point for survodutide is that its identity is defined by glucagon-receptor recruitment without GIP a deliberately narrower, more liver-focused design than the triple agonists