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The primary actions include: Slowing gastric emptying, which means food remains in your stomach longer, promoting feelings of fullness Acting on appetite centres in the brain to reduce hunger signals and food cravings Improving insulin sensitivity and glucose metabolism in people with or at risk of type 2 diabetes Potentially influencing eating behaviours through effects on brain signalling pathways These medications are absorbed systemically and distributed throughout the body via the bloodstream

TDI- total daily insulin

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Patch-clamp electrophysiology Patch-clamp experimental procedures are detailed in the Supplementary Materials and Methods