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Unlike powdered frozen tissue, frozen whole blood or serum requires thawing which could increase vulnerability to the auto-oxidation or degradation thus far established

The initiation of ferroptosis requires a critical damage threshold, which is determined by the dynamic balance of multiple factors, such as the intracellular free iron concentration, lipid peroxidation levels, GSH reserves, and GPX4 activity

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This will be of considerable potential since utilization of these modulators in combination with conventional chemotherapeutic drugs will overcome the frequently observed phenomenon of cancer recurrence, and additionally treat various developmental and metabolic disorders with elan and success