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GLP-1 and its analogues have been shown to possess direct effects on improving cardiomyocyte viability, cardiac function, and vasodilation

Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)

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Chemical chaperones mitigate experimental asthma by attenuating endoplasmic reticulum stress