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Some insurance plans require the patient to try losing weight through a physician-supervised weight loss program before they will cover Contrave. The Aetna plans that list Contrave as a non-preferred brand also typically require prior authorization

Notably, GLP-1 analogs that can pass the BBB have been shown to produce strong neuroprotective effects in preclinical models of Alzheimers disease, Parkinsons disease, stroke, and other neurological conditions

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