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Although discovered several decades ago, studies continue to identify pro-inflammatory roles for leptin and anti-inflammatory activities for adiponectin, hormones secreted in large amounts by the adipocyte

For example, cagrilintide can reduce the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), two potent orexigenic peptides, and increase the expression of proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART), two anorexigenic peptides, in the arcuate nucleus of the hypothalamus (Roth et al., 2018, Physiol Behav)

Essential support for anemia, pregnancy, TPN, and chemotherapy

Controlled studies using validated appetite scales showed decreased hunger, increased satiety and reduced prospective food consumption scores with GLP-1 treatment, which translated into lower energy intake and weight reduction