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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

By removing dissolved organics and fine particulates, BAC improves the overall performance of the treatment train

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Snchez Prez MJ, Gonzlez-Reimers E, Santolaria-Fernndez F, de la Vega-Prieto MJ, Martnez-Riera A, Gonzlez PA, Rodrguez Rodrguez E, Durn-Castelln MC (2006) Lipid peroxidation and serum cytokines in acute alcoholic hepatitis