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Factors to Weight Loss Resistance Several factors contribute to weight loss resistance, including thyroid and sex hormone imbalances, lack of exercise, chronic sleep deprivation, metabolic slowdown from chronic dieting, food allergies, gut dysbiosis, high cortisol levels due to chronic stress, insulin resistance, and exposure to environmental toxins

Conversely, hyperplastic obesity may protect against obesity-associated metabolic comorbidities [42,43,44]

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