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Gaertner S, Cordeanu EM, Mirea C, Frantz AS, Auger C, Bilbault P, Ohlmann P, Schini-Kerth V, Stephan D (2018) Increased risk and severity of unprovoked venous thromboembolism with clustering cardiovascular risk factors for atherosclerosis: results of the REMOTEV registry

So right now, aleniglipron is actually the only oral SM GLP-1RA with disclosed Phase 2b weight loss data in the same ballpark as orforgliprons ~12.4% at 36 mg/72 wks from ATTAIN-1, with Phase 3 planned mid-2026

ACG guidelines for prevention of NSAID-related ulcer complications

Therefore, discussing the anticoagulant activity of nutritional supplements with a doctor is essential