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Gene Editing and CRISPR in the Clinic: Current and Future Perspectives

These typically resolve within several weeks as the body adjusts to treatment

In some embodiments, therapeutically acceptable otic formulations are: The formulations disclosed herein alternatively encompass an otoprotectant agent in addition to the at least one active agent and/or excipients, including but not limited to such agents as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that may arise from the use of specific therapeutic agents or excipients, diluents or carriers

Figure 1: Data taken from Bays et al., 2026 An important point to note appears in the post-treatment follow-up data regarding maintained weight-loss