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Allergy Drug Discov

These active sites react with peroxide to make selenenic acid (Se-OH), which is then reduced into glutathione (GSH) by the glutathione reductase (GR) enzyme to produce glutathiolated selenol (Se-SG) intermediate

Paraformaldehyde was purchased from Biosharp Life Sciences (Hefei, China), and DAPI (4,6-diamidino-2-phenylindole) was obtained from Beyotime Biotechnology, (Jiangsu, China)

903 In a RANKL-induced osteoclast model, the bisphosphonate zoledronic acid promotes ferroptosis by increasing Fe 2+ , ROS, and MDA levels, and decreasing GPX4 and GSH levels