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Although there is no clinical trial underway specifically evaluating the safety and efficacy of combination therapy of BRAF inhibitor plus MEK inhibitor in MM, a retrospective study in Japan showed that MM/AM and CM exhibited similar response rates to combined BRAF and MEK suppression (64.3% vs 76.5%) (139), suggesting the potential efficiency of dual repression of BRAF and MEK in MM

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It is generally considered safe for adults of all ages, though use in children or teenagers should be discussed with a healthcare provider to ensure it aligns with their specific developmental needs

Inhibitory KORD-DREADD expression in the OB resulted in increased chow intake in RD mice, whereas excitatory hM3Dq-DREADD induced a decreased chow and high-fat high-sucrose diet in WD mice