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doi: 10.1016/j.jcte.2024.100340

The body makes its own choline, but levels can drop with age, toxic exposures, or chronic illness

In the Diabetes Prevention Program Outcomes Study (DPPOS, N=1,800), metformin use for a mean of 12.7 years was associated with a 13% prevalence of B12 deficiency versus 5.4% in the placebo group (P 9%) impairs wound healing regardless of peptide use [4]