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In line with these reports, we found that hepatic Pparg expression was drastically elevated by HFD feeding and significantly reduced in GPR146-deficient mice at both mRNA and protein levels (Supplementary Fig

Subsequent work in lean PCOS extended these metabolic and androgenic improvements, although sample sizes were modest and follow-up was short

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Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss