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It can be difficult to determine whether a symptom is directly caused by the medication, related to rapid weight loss, influenced by other medications, or tied to underlying health conditions

Similarly, the STEP 4 trial found that patients who discontinued semaglutide and switched to a placebo for 48 weeks regained 6.9% of their body weight

"As with many emerging medical interventions, athletes, coaches, agents, physicians and performance staff are asking questions about their potential benefits and risks." The growing interest has caught the attention of watchdogs, too

It targets three key receptors : GLP-1, GIP, and glucagon receptors