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Mizuhara, N., Kuroda, M., Ogita, A., Tanaka, T., Usuki, Y., and Fujita, K., Bioorgan

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1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection (Young et al., 1990) and the overall mortality rate remains high at 25%50%, despite advances in critical care