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This epigenetic derepression allows senescence-promoting gene expression to increase even when SIRT1 and FOXO3 protein activity is nominally intact a mechanism by which methylation cycle impairment undermines the longevity gene regulatory program from the chromatin level
10.1016/j.neuroscience.2010.11.063 156
TXNs are considered members of the thioredoxin family of proteins based on the comparative sequence analysis, presence of common motif WCPPC of the oxidoreductase superfamily in their catalytic center and some other features that are conserved throughout this type of oxidoreductases
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