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The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Yes, just as a vitamin deficiency can lead to symptoms such as fatigue, hair loss, or depression, an overdose of vitamins can also cause other issues such as stomach pain, diarrhea, or kidney stones
In consideration of the dual roles of GLP-1RAs in hypoglycemic effects and preventing CVD among T2DM patients, we reviewed the cardiovascular effects and molecular mechanisms of GLP-1RAs in CVOTs, animal models and cultured cells, and discuss how these findings transform pharmacotherapies for T2DM, and even expand the indication of this important category of anti-diabetic drugs to CVD patients without diabetes
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