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As Avne thermal water profoundly reduces the colonization of pathogenic bacteria such as Staphylococcus aureus in AD lesions, the inhibition of inflammatory interleukins (IL-8) (responsible for AD aggression and the regulation of the enzymatic activities of proteases, b-glucocerebrosidases, and phospholipase A2 to restore the AD rupture skin barrier and ameliorate AD symptoms, resulting in soothing and antipruritic effects) could be responsible for its therapeutic effects

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Alterations of hHrd1 expression are related to hyperphosphorylated tau in the hippocampus in Alzheimers disease