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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

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The decrease in mean GFR at 52 weeks was smaller in the high (1.5 mg) and low dose dulaglutide (0.75 mg) treatment groups (both 0.7 ml/min/1.73 m2) vs