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5 Overall, these mechanisms support the concept that body weight and fat mass are regulated by a number of physiological mechanisms beyond voluntary food intake and physical exercise

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Common side effects: Headache Upper respiratory infection symptoms (sore throat, runny/stuffy nose) Constipation Vomiting Mouth ulcers Rare but serious side effects: Heart failure (shortness of breath, swelling, sudden weight gain) Pancreatitis (persistent nausea/vomiting, severe abdominal or back pain) Allergic reactions (hives, facial swelling, difficulty breathing) Hypoglycemia when combined with insulin or sulfonylureas (hunger, sweating, confusion) Kidney problems (decreased function or failure requiring dialysis) Severe skin reactions (blisters, skin erosion) Severe joint pain What should you tell your healthcare provider before taking Januvia

Among these, elevated plasma levels of L-leucine and coumarin, together with reduced betaine, emerged as notable features