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Supported by the substantial weight-loss efficacy of the GLP-1MK-801 conjugate and the potentiated hypothalamic changes in transcripts and proteins related to NMDA receptor-linked neuroplasticity, the alteration in MK-801 biodistribution governed by GLP-1-mediated targeting may effectively bypass the delivery of MK-801 to vagal afferent target neurons in the nucleus of the solitary tract

Since the small bowel, especially the, terminal ileum, is rich in macrophages there is no reasonable explanation for small bowel sparing by this process

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The GHK part is a three amino acid peptide of glycine-histidine-lysine that can be found naturally in yucky bodily fluids (if you are wondering in plasma, saliva, and urine)