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Oral iron supplements are typically first-line, with UK standard dosing being ferrous sulphate 200 mg, ferrous fumarate 210 mg, or ferrous gluconate 300 mg once daily or on alternate days (alternate-day dosing may improve tolerance)

AGEs promote oxidative stress and inflammation, leading to the further damage of neurons [16]

Dual luciferase reporter assay Reporter plasmids of PPARa were constructed and cloned into the GV712 luciferase vector (Component sequence: CMV enhancer-MCS-SV40-puromycin)