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Barbara Kahn of Harvard Medical School, this relationship was one of the original reasons NNMT was studied as a possible regulatory factor in obesity and metabolic imbalance

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Peripherally acting anti-obesity medicines with evidence for use in older adults Orlistat Weight loss trials None of the XENDOS trial participants were older adults, and hence the results from this study may not be applicable to an ageing population, although as the drug works peripherally there is no reason to suggest reduced efficacy or safety in elderly patients