tirzepatide and arthritis TOGETHER-PsA:Tirzepatide + Ixekizumab Rapidly Improves PsA Disease Control With Obesity/Overweight New Tirzepatide trial confirms benefits

This slowing contributes to the appetite suppression that drives weight loss and the postprandial glucose-lowering effect, and it also drives most of the gastrointestinal side effect profile.[1],[2] A 2025 review in the Journal of Clinical Endocrinology & Metabolism summarizes the published evidence: GLP-1 receptor agonists impact gastric, intestinal, and gallbladder motility simultaneously, with effects on gastric fundus relaxation, antral contractility inhibition, increased pyloric tone, and reduced small intestinal motility.[3] The path from this mechanism to constipation is straightforward

Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice

This paper explains how immune cells from women fail to inactive X chromosome (which encodes for TLR7 and other immune molecules), and explains, at least in part, the female predominance in SLE

Gallwn ystyried agor siopau profiad all-lein neu siopau naid i alluogi defnyddwyr i brofi effeithiau'r cynnyrch yn fwy greddfol