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A.FontanaudP.BoisP.BabutyD.et al (2012)

In a retrospective series of over 2,000 compounded lipotropic injections, the incidence of systemic hypersensitivity was below 0.1 percent, yet clinicians should maintain readiness to administer intramuscular epinephrine and transfer patients to higher-level care when indicated

Adicionalmente, la sibutramina produce un aumento de la frecuencia cardiaca y la presin sangunea, que pueden ser clnicamente significativas en algunos pacientes, habindose registrado casos de arritmias, cardiopatas isqumicas y accidentes vasculares graves con su consumo