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It has been hypothesised that targeting three complementary pathways simultaneously may help to counteract some of the physiological adaptations such as compensatory increases in hunger that can limit the effectiveness of existing treatments, though this remains to be confirmed in clinical studies

10.3390/ijms231911160 140 KimC

Figure 1 Signaling pathways involved in macrophage activation in CKD-associated vascular inflammation Macrophages are pivotal contributors to vascular inflammation in CKD, driven by various signaling pathways that regulate their activation

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