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Glycation liability: The single lysine residue in the sequence can react with reducing sugars sometimes used as bulking agents in lyophilized peptide products, which is why compounding formulations favor non-reducing alternatives like trehalose or mannitol

The logics of this approach, where FRET is enhanced due to the translational diffusion as a donor-acceptor pair that is too far apart for efficient transfer at the instant of excitation may diffuse toward each other during the excited-state lifetime so that the distance between them becomes short enough for efficient transfer (Elkana et al., 1968