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A pigeon may appear exceptionally light and athletic, leading the fancier to believe it is in perfect condition, while in reality it may be lacking the energy stores required for peak performance

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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

People with certain health conditions, like kidney disease, are at a higher risk of imbalances in electrolytes, including potassium