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It must include a healthy diet, and regular exercise

In a 24-week, double-blind, randomized trial, patients treated with metformin HCl immediate-release 500 mg twice daily for at least 8 weeks were randomized to continued treatment with metformin HCl immediate-release 500 mg twice daily or to metformin HCl extended-release either 1,000 mg once daily or 1,500 mg once daily

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