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In the phase 2 NEJM 2023 trial, the net glycaemic effect of retatrutide was favourable improvements in fasting glucose and insulin resistance markers were observed suggesting that the insulin-stimulating effects of GLP-1R and GIPR agonism counterbalanced any glucose-raising tendency from glucagon receptor activation

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Arrhythmias, or irregular heartbeats, are a noted concern when using this medication over prolonged periods

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By removing them, scientists aim to make tissues feel younger, reduce inflammation, and slow down aging

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