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At the peripheral level, gut microbiota dysbiosis and a reduction in microbial metabolitesparticularly SCFAspromote increased antigen exposure and activation of innate immune responses

In this study, we established a morphine-induced constipation mouse model, characterized by small intestinal dysfunction, including reductions in fecal output, fecal water content, the motility and the transit rate of small intestines

This selectivity means potential hair benefits without the systemic hormonal effects associated with pharmaceutical 5-alpha reductase inhibitors like finasteride

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