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reported that chronic administration of IGF-1 increases the density of NMDA receptors (NMDAR1, NMDAR2A, and R2B subunits) in the hippocampus, dentate gyrus and cortical areas, which are mainly involved in learning and memory [48]

This is intentional, and it significantly reduces the likelihood of nausea and other gastrointestinal side effects that some patients experience early in treatment

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