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Functional decline is accelerated in skeletal muscle and peripheral nerves due to advanced glycation end-product deposition, ectopic lipid accumulation, and impaired glucose uptake

Shields BM, TJ MD, Oram R, Hill A, Hudson M, Leete P, et al

NNMT is highly expressed in the white adipose tissue of individuals with obesity and diabetes, where it acts as a "metabolic brake," slowing down the rate at which cells burn energy