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2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

Table 1 Description and level of evidence for articles reviewed

It potentially does so through its effects on serotonin uptake and antioxidant activity in the brain

It is often described in scientific literature as a stable gastric pentadecapeptide, with the amino acid sequence GEPPPGKPADDAGLV and a molecular weight of approximately 1419 Da