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Other socioeconomic factor may factor in to this, such as the high cost of GLP-1RAs (which can limit affordability for lower-income patients and those with Medicaid compared to private insurance coverage), formulary restrictions, provider-level prescribing bias, and patient-level preferences 16

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Unlike food intake, oral administration of a glucose bolus revealed no significant differences in GIP and GLP-1 levels in PAR2 mutants versus WT mice (Figure 1M), suggesting that food uptake induced specific proteolytic alterations that especially contributed to GIP release

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