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Most genes, including Casp1 and Ptgs2os2 (a positive regulator of Cox-2 expression in cis and pro-inflammatory response regulator in trans ), showed a negative correlation between relative gene expression and the level of DNA methylation at that genes promoter site (Fig

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In Supplementary Figure S4, the same highfat, AGEpromoting protocol yields the characteristic hairloss phenotype commonly linked to AGEassociated skin manifestations in diabetes mellitus 69