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Various effects might be due to different IGF-1 levels

Key Takeaways GLP-1 receptor agonists (GLP-1 RAs)including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)cause weight loss primarily by suppressing appetite, which can lead to a caloric deficit deep enough to trigger lean body mass (LBM) loss alongside fat loss

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Chronic cerebral hypoperfusion induces microglial activation, polarized toward M1 (pro-inflammatory) phenotype, and the drug fingolimod has been shown, in an animal model, to attenuate such microglia-mediated neuroinflammation and to promote oligodendrocytogenesis by shifting microglia toward M2 subtype (217)