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Patients with a prior history of serious gastrointestinal adverse events and other known risk factors that are associated with peptic ulcer disease ( alcoholism, smoking) are at increased risk

Significantly, as shown in Figure 6 in their Extended Data ( only to the inactive M pro C145A mutant, and concluded it was a likely M pro substrate, because they were able to identify a putative M pro cleavage site in the TRMT1 protein sequence (PRLQ/ANFT), where the slash (/) represents the cleavage site

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doi:10.1016/s0002-9149(02)03144-2 8